Search results for "Loading rate"

Running in highly cushioned shoes increases leg stiffness and amplifies impact loading

2018

AbstractRunning shoe cushioning has become a standard method for managing impact loading and consequent injuries due to running. However, despite decades of shoe technology developments and the fact that shoes have become increasingly cushioned, aimed to ease the impact on runners’ legs, running injuries have not decreased. To better understand the shoe cushioning paradox, we examined impact loading and the spring-like mechanics of running in a conventional control running shoe and a highly cushioned maximalist shoe at two training speeds, 10 and 14.5 km/h. We found that highly cushioned maximalist shoes alter spring-like running mechanics and amplify rather than attenuate impact loading. T…

Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period

2011

Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …

Aerobic granular sludge treating anaerobically pretreated brewery wastewater at different loading rates.

2020

Abstract In this study, three different aerobic granular sludge (AGS) reactors fed with anaerobically pre-treated brewery wastewater were studied. The AGS reactors were operated under different conditions including organic loading rates (OLR) between 0.8 and 4.1 kg COD m−3 d−1, C:N:P ratios (100:10:1 and 100:6:1) and food to microorganism ratios (F/M) between 0.8 ± 0.6 and 1.2 ± 0.5 and 0.9 ± 0.3 kg-TCOD kg-VSS−1d−1. Stable granulation was achieved within two weeks and the size of the granules increased according to the OLR applied. The results indicated that low C:N:P and F/M ratios were favorable to achieve stable aerobic granules in the long term. The carbon removal rate was load-indepen…

Simultaneous nitrogen and organic carbon removal in aerobic granular sludge reactors operated with high dissolved oxygen concentration

2013

Simultaneous nitrification and denitrification (SND) together with organic removal in granules is usually carried out without Dissolved Oxygen (DO) concentration control, at ‘‘low DO’’ (with a DO 7–8 mg/L, during feast and famine conditions respectively). In particular, different strategies of cultivation and several organic and nitrogen loading rate have been applied, in order to eval- uate the efficiencies in SND process without dissolved oxygen control. The results show that, even under conditions of high DO concentration, nitrogen and organic matter can be simultaneously removed, with efficiency >90%. Nevertheless, the biological conditions in the inner layer of the granule may change sig- …

The effect of organic loading rate and retention time on hydrogen production from a methanogenic CSTR.

2011

Abstract The possibility of shifting a methanogenic process for hydrogen production by changing the process parameters viz., organic loading rate (OLR) and hydraulic retention time (HRT) was evaluated. At first, two parallel semi-continuously fed continuously stirred tank reactors (CSTR) were operated as methanogenic reactors (M1 and M2) for 78 days. Results showed that a methane yield of 198–218 L/kg volatile solids fed (VS fed ) was obtained when fed with grass silage at an OLR of 2 kgVS/m 3 /d and HRT of 30 days. After 78 days of operation, hydrogen production was induced in M2 by increasing the OLR from 2 to 10 kgVS/m 3 /d and shortening the HRT from 30 to 6 days. The highest H 2 yield …

Effect of fatigue and gender on kinematics and ground reaction forces variables in recreational runners.

2017

The presence of fatigue has been shown to modify running biomechanics. Overall in terms of gender, women are at lower risk than men for sustaining running-related injuries, although it depends on the factors taken into account. One possible reason for these differences in the injury rate and location might be the dissimilar running patterns between men and women. The purpose of this study was to determine the effect of fatigue and gender on the kinematic and ground reaction forces (GRF) parameters in recreational runners. Fifty-seven participants (28 males and 29 females) had kinematic and GRF variables measured while running at speed of 3.3 m s−1 before and after a fatigue test protocol. T…

2019

Atomic force microscopy (AFM) is today an established tool in imaging and determination of mechanical properties of biomaterials. Due to their complex organization, those materials show intricate properties such as viscoelasticity. Therefore, one has to consider that the loading rate at which the sample is probed will lead to different mechanical response (properties). In this work, we studied the dependence of the mechanical properties of endothelial cells on the loading rate using AFM in force spectroscopy mode. We employed a sharp, four-sided pyramidal indenter and loading rates ranging from 0.5 to 20 μm/s. In addition, by variation of the load (applied forces from 100 to 10,000 pN), the…

Measuring (biological) materials mechanics with atomic force microscopy. 2. Influence of the loading rate and applied force (colloidal particles)

2020

Atomic force microscopy (AFM) is the most often used tool to study the mechanical properties of eukaryotic cells. Due to their complex assembly, cells show viscoelastic properties. When performing experiments, one has to consider the influence of both loading rate and maximum load on the measured mechanical properties. Here, we employed colloidal particles of various sizes (from 2 to 20 μm diameter) to perform force spectroscopy measurements on endothelial cells at loading rates varying from 0.1 to 50 μm/s, and maximum loads ranging from 1 to 25 nN. We were able to determine the non-linear dependence of cell viscoelastic properties on the loading rate which followed a weak power law. In add…

Comparison of Activated Sludge Processes at Different Temperatures: 35°C, 27–55°C, and 55°C

2002

The performance of mesophilic (35°C; referred to as R1) and thermophilic (55°C; R3) laboratory activated sludge processes (ASPs) as well as ASP with a fluctuating temperature (27-56°C; R2) was compared. During the 124-day runs, in R1 and R3 hydraulic retention time was gradually reduced from 18 h to 3 h, corresponding to an increase in volumetric loading rate from 2 to 10 kg soluble COD m−3d−1; in R2 hydraulic retention time was gradually reduced from 18 to 4.5 h, corresponding to an increase in volumetric loading rate from 2 to 7.5 kg soluble COD m−3d−1. R1 removed on average 85% of soluble COD (GF50-filtered) that was approximately 10% more than R3. In R2 SCOD removal was dependent on the…

Viscoelastic properties of the Achilles tendon in vivo

2013

It has been postulated that human tendons are viscoelastic and their mechanical properties time-dependent. Although Achilles tendon (AT) mechanics are widely reported, there is no consensus about AT viscoelastic properties such as loading rate dependency or hysteresis, in vivo. AT force-elongation characteristics were determined from 14 subjects in an ankle dynamometer at different loading rates using motion capture assisted ultrasonography. AT stiffness and elongation were determined between 10 – 80% of maximum voluntary contraction (MVC) force at fast and slow loading rates. As subjects were unable to consistently match the target unloading rate in the slow condition, AT hysteresis was on…